White Papers

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A comprehensive report that can serve as a starting point for any strategic indication prioritization exercise covering 21 major oncology tumors.

First Principles gives its view on the rapid changes in the gene therapy field in 2018 and 2019, trying to give insight on the ability of gene therapy to get beyond niche indications.

Pharmaceutical pricing is perhaps most controversial and enigmatic issue facing pharma today. This extensive paper crosses many topics to review the economic mechanisms beyond price and where it may go tomorrow. This paper will also be presented in blog form given the extensive nature of the topic.

In this paper written in 2017, First Principles surveys the CAR-T landscape to discuss clinical challenges in these therapies as compared to past innovations.